Thermodynamic Insights of the Molecular Interactions of Dopamine (Neurotransmitter) with Anionic Surfactant in Non-Aqueous Media
Document Type
Article
Publication Date
9-1-2023
Abstract
This study was aimed at establishing the interactions prevailing in an anionic surfactant, sodium dodecyl sulfate, and dopamine hydrochloride in an alcoholic (ethanol) media by using volumetric, conductometric, and tensiometric techniques. Various methods were utilized to estimate the critical micelle concentration (cmc) values at different temperatures. The entire methods yielded the same cmc values. The corresponding thermodynamic parameters viz. the standard free energy of micellization (Gmico), enthalpy of micellization (Hmico), and entropy of micellization (Smico) were predicted by applying the pseudo-phase separation model. The experimental density data at different temperatures (298.15 K, 303.15 K, 308.15 K, and 313.15 K) were utilized to estimate the apparent molar volumes (V & phi;o) at an infinite dilution, apparent molar volumes (V & phi;cmc) at the critical micelle concentration, and apparent molar volumes (& UDelta;V & phi;m) upon micellization. Various micellar and interfacial parameters, for example, the surface excess concentration (& UGamma;max), standard Gibbs free energy of adsorption at the interface (& UDelta;Goad), and the minimum surface area per molecule (Amin), were appraised using the surface tension data. The results were used to interpret the intermolecular interactions prevailing in the mixed systems under the specified experimental conditions.
Keywords
anionic surfactant, critical micelle concentration, thermodynamic properties, drug-surfactant interactions
Divisions
CHEMISTRY
Publication Title
Pharmaceuticals
Volume
16
Issue
9
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND