Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application
Document Type
Article
Publication Date
8-1-2023
Abstract
Bi-modal imaging contrast agent has attracted considerable attention in medical physics research field via quantum dots (QDs) fabrications. Doped quantum dots are playing an important role in seeking alternatives to conventional heavy metal-containing particles for medical applications. In order to improve imaging diagnosis, herein we report the design and synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent. The medium, mercaptopropionic acid (MPA) capped Mn:ZnSe QDs surface-conjugated with a commercial contrast agent (Iohexol), was synthesized in seeking to overcome the limitations of Iohexol, also towards advancing bi-modal imaging approaches. In this study, morphology, elemental, absorption and fluorescence analysis were investi-gated, followed by a preliminary study of CT contrast enhancement and cell viability. In comparison to Iohexol, the fluorescence of I@MPA-Mn:ZnSe is observed at 585 nm. The CT Hounsfield unit (HU) increases linearly with mass concentration, with a four-fold increment in HU over that of Iohexol, producing greater than 328 Delta HU at similar concentrations, confirming the CT contrast efficiency of I@MPA-Mn:ZnSe. Cytotoxicity studies have confirmed that the medium possesses good biocompatibility and low toxicity to cells (HepG2 and MDA-MB-321). Present results for CT enhancement and brightness of fluorescence of I@MPA-Mn:ZnSe point to its great potential as a bi-modal contrast medium for further diagnosis applications.
Keywords
Bi-modal, Contrast agent, CT scan, Mn doped ZnSe, Iohexol, Quantum dots
Divisions
oncology,PHYSICS,pharlife
Funders
Universiti Malaya under Impact-Oriented Interdisciplinary Research Grant Programme (IIRG) IIRG001B-19FNW,Fundamental Research Grant Scheme (FRGS) of the Ministry of Education Malaysia FRGS/1/2018/STG01/UM/02/14 & FRGS/1/2020/STG05/UM/02/5
Publication Title
Radiation Physics and Chemistry
Volume
209
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND