Alkaloids of Cryptocarya griffithiana Wight. (syn. Cryptocarya infectoria Miq.) and their chemotaxonomic significance
Document Type
Article
Publication Date
8-1-2023
Abstract
The phytochemical investigation on the bark of Cryptocarya griffithiana Wight. (syn. Cryptocarya infectoria Miq.) resulted in the isolation and identification of six isoquinoline-derived alkaloids known as (+)-N-methyl-isococlaurine (1), (+)-reticuline (2), (+)-laurotetanine (3), (+)-N-methyllaurotetanine (4), atherosperminine (5), and argentinine (6), while the leaf extract yielded two alkaloids namely argentinine (6) and liriodenine (7). The structures were elucidated by extensive analyses of 1D and 2D NMR (COSY, HSQC, and HMBC) spectroscopy in combination with MS, and literature values. The alkaloids 2, 3, 6, and 7 are reported for the first time from this species and are regarded as significant for the genus Cryptocarya. Furthermore, this is the first report on the isolation of 6 and 7 from the genus Cryptocarya, which indicates that C. griffithiana holds considerable chemo-taxonomic importance within the genus. Our findings showed that this plant is rich in isoquinoline alkaloids and possessed a strong relationship with other Cryptocarya species.
Keywords
Cryptocarya griffithiana, Cryptocarya infectoria, Alkaloid, Lauraceae, Isoquinoline
Divisions
CHEMISTRY
Funders
UiTM Dynamic Research Grant [Grant No: 600-RMC/DINAMIK-POSTDOC 5/3-006/2020],Department of Chemistry, Faculty of Science, University of Malaya
Publication Title
Biochemical Systematics and Ecology
Volume
109
Publisher
Pergamon-Elsevier Science Ltd
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND