Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents
Document Type
Article
Publication Date
7-1-2023
Abstract
Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird's nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models. Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides. Bioactive compounds in EBN, especially sialic acid, add value to neurotrophic potential of EBN and contribute to neuronal repair and protection. Various studies reporting the neuroprotective effects of EBN, their molecular mechanisms, and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.(c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords
Antioxidant, Composition, Edible bird nest, Neurodegenerative disease, Neuroprotection, Sialylated mucin glycopeptide
Divisions
pharlife,ummc
Funders
Research Excellence Consortium by Ministry of Higher Education, Malaysia (Grant No: KKP/2020/UKM-UKM/5/1),Fundamental Research Grant Scheme (FRGS) (Grant No: FP016- 2019A & FRGS/1/2019/SKK09/UM/02/2)
Publication Title
Food Science and Human Wellness
Volume
12
Issue
4
Publisher
KeAi Publishing Ltd
Publisher Location
16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG DISTRICT 100009, PEOPLES R CHINA