Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells
Document Type
Article
Publication Date
6-1-2023
Abstract
In this study, the chemotherapeutic effect of a-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.
Keywords
& alpha, -mangostin, mammary cancer, LA7 cells, apoptosis, immunohistochemistry, antioxidant
Divisions
cenar,pharchemistry
Funders
University of Malaya through the Postgraduate Research Fund (PPP) (PG 141-2012B),University Malaya Research Grant (FL001E-13BIO),Ministry of Education, Malaysia (UM-MOHE M.C/625/1/HIR/MOHE//SC/09)
Publication Title
International Journal of Molecular Sciences
Volume
24
Issue
12
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND