Antimalarial ceramicines Q-T from Chisocheton ceramicus
Document Type
Article
Publication Date
6-1-2023
Abstract
Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated C-13 chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanonea] phenanthren ring system with a beta-furyl ring at C-17, and without a tetrahydrofuran ring like ceramicine B, which is characteristic of known ceramicines. Ceramicine R (2) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.8 mu M. GRAPHICS] .
Keywords
Ceramicines Q-T, Limonoids, Chisocheton ceramicus, Meliaceae, Antimalarial activity
Divisions
CHEMISTRY
Funders
Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No: JP 19K07152; JP 22K06671; JP 16K08309]
Publication Title
Journal of Natural Medicines
Volume
77
Issue
3
Publisher
Springer Japan KK
Publisher Location
SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005, JAPAN