Antimalarial ceramicines Q-T from Chisocheton ceramicus

Authors

• Alfarius Eko Nugroho
• Chin Piow Wong
• Yusuke Hirasawa
• Toshio Kaneda
• Takahiro Tougan
• Toshihiro Horii
• A. Hamid A. Hadi
• Hiroshi Morita

Document Type

Article

Publication Date

6-1-2023

Abstract

Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated C-13 chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanonea] phenanthren ring system with a beta-furyl ring at C-17, and without a tetrahydrofuran ring like ceramicine B, which is characteristic of known ceramicines. Ceramicine R (2) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.8 mu M. GRAPHICS] .

Keywords

Ceramicines Q-T, Limonoids, Chisocheton ceramicus, Meliaceae, Antimalarial activity

Publication Title

Journal of Natural Medicines

Recommended Citation

Nugroho, Alfarius Eko; Wong, Chin Piow; Hirasawa, Yusuke; Kaneda, Toshio; Tougan, Takahiro; Horii, Toshihiro; Hadi, A. Hamid A.; and Morita, Hiroshi, "Antimalarial ceramicines Q-T from Chisocheton ceramicus" (2023). Research Publications (2021 to 2025). 3163.
https://knova.um.edu.my/research_publications_2021_2025/3163

Divisions

CHEMISTRY

Funders

Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No: JP 19K07152; JP 22K06671; JP 16K08309]

Volume

77

Issue

3

Publisher

Springer Japan KK

Publisher Location

SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005, JAPAN