Antibacterial and antifungal terpenes from the medicinal angiosperms of Asia and The Pacific: Haystacks and gold needles
Document Type
Article
Publication Date
5-1-2023
Abstract
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the Pacific with antibacterial and/or antifungal activities and analyses their distribution, molecular mass, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and library searches from 1968 to 2022. About 300 antibacterial and/or antifungal terpenes were identified during this period. Terpenes with a MIC <= 2 mu g/mL are mostly amphiphilic and active against Gram-positive bacteria, with a molecular mass ranging from about 150 to 550 g/mol, and a polar surface area around 20 angstrom(2). Carvacrol, celastrol, cuminol, dysoxyhainic acid I, ent-1 beta,14 beta-diacetoxy-7 alpha-hydroxykaur-16-en-15-one, ergosterol-5,8-endoperoxide, geranylgeraniol, gossypol, 16 alpha-hydroxy-cleroda-3,13 (14)Z-diene-15,16-olide, 7-hydroxycadalene, 17-hydroxyjolkinolide B, (20R)-3 beta-hydroxy-24,25,26,27-tetranor-5 alpha cycloartan-23,21-olide, mansonone F, (+)-6,6'-methoxygossypol, polygodial, pristimerin, terpinen-4-ol, and alpha-terpineol are chemical frameworks that could be candidates for the further development of lead antibacterial or antifungal drugs.
Keywords
Antibacterial terpenes, Antifungal terpenes, Medicinal plants, Asia, Pacific
Divisions
medbio,CHEMISTRY
Funders
None
Publication Title
Molecules
Volume
28
Issue
9
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND