Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura
Document Type
Article
Publication Date
4-1-2023
Abstract
Eight undescribed iboga alkaloids, polyneurines A-H, were isolated from the bark of Tabernaemontana polyneura. The structures of these alkaloids were established by interpretation of the MS and NMR data, while the con-figurations were determined using GIAO NMR calculations and DP4+ probability analysis, TDDFT-ECD method, or X-ray diffraction analysis. Polyneurine A possesses a y-lactone unit embedded within the iboga skeleton, while polyneurines D and E incorporate a formylmethyl moiety at C-3 of the iboga skeleton. Biosynthetic pathways towards the formation of polyneurines A, C, D, and E were proposed.
Keywords
Tabernaemontana polyneura, Apocynaceae, Iboga, Alkaloids, ECD, DP4+, X-ray diffraction
Divisions
InstituteofBiologicalSciences,CHEMISTRY
Funders
Universiti Malaya and MOHE Malaysia (FRGS/1/2019/STG01/UM/02/23)
Publication Title
Phytochemistry
Volume
208
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND