Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium
Document Type
Article
Publication Date
6-1-2022
Abstract
Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.
Keywords
Pyranocoumarin, Coumarin, Calophyllum scriblitifolium, Antimalarial activity, Caloforines A-G
Divisions
CHEMISTRY
Funders
Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No; JP 19K07152],JSPS KAKENHI, Japan [Grant No; JP 16K08309]
Publication Title
Journal of Natural Medicines
Volume
76
Issue
3
Publisher
Springer Verlag (Germany)
Publisher Location
SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005, JAPAN