Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium

Authors

• Ai Ogasawara
• Ryo Noguchi
• Takuya Shigi
• Alfarius Eko Nugroho
• Yusuke Hirasawa
• Toshio Kaneda
• Takahiro Tougan
• Toshihiro Horii
• A. Hamid A. Hadi
• Hiroshi Morita

Document Type

Article

Publication Date

6-1-2022

Abstract

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.

Keywords

Pyranocoumarin, Coumarin, Calophyllum scriblitifolium, Antimalarial activity, Caloforines A-G

Publication Title

Journal of Natural Medicines

Recommended Citation

Ogasawara, Ai; Noguchi, Ryo; Shigi, Takuya; Nugroho, Alfarius Eko; Hirasawa, Yusuke; Kaneda, Toshio; Tougan, Takahiro; Horii, Toshihiro; Hadi, A. Hamid A.; and Morita, Hiroshi, "Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium" (2022). Research Publications (2021 to 2025). 286.
https://knova.um.edu.my/research_publications_2021_2025/286

Divisions

CHEMISTRY

Funders

Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No; JP 19K07152],JSPS KAKENHI, Japan [Grant No; JP 16K08309]

Volume

76

Issue

3

Publisher

Springer Verlag (Germany)

Publisher Location

SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005, JAPAN