Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry (TM)
Document Type
Article
Publication Date
4-1-2023
Abstract
Chronic hepatitis B (CHB) infection is one of the most common causes of cirrhosis and liver cancer worldwide. Our aim was to assess clinical and patient-reported outcome (PRO) profile of CHB patients from different regions of the world using the Global Liver Registry. The CHB patients seen in real-world practices are being enrolled in the Global Liver Registry. Clinical and PRO (FACIT-F, CLDQ, WPAI) data were collected and compared to baseline data from CHB controls from clinical trials. The study included 1818 HBV subjects (48 +/- 13 years, 58% male, 14% advanced fibrosis, 7% cirrhosis) from 15 countries in 6/7 Global Burden of Disease super-regions. The rates of advanced fibrosis varied (3-24%). The lowest PRO scores across multiple domains were in HBV subjects from the Middle East/North Africa (MENA), the highest - Southeast/East and South Asia. Subjects with advanced fibrosis had PRO impairment in 3 CLDQ domains, Activity of WPAI (p < 0.05). HBV subjects with superimposed fatty liver had more PRO impairments. In multivariate analysis adjusted for location, predictors of PRO impairment in CHB included female sex, advanced fibrosis, and non-hepatic comorbidities (p < 0.05). In comparison to Global Liver Registry patients, 242 controls from clinical trials had better PRO scores (Abdominal, Emotional, and Systemic scores of CLDQ, all domains of WPAI) (p < 0.05). In multivariate analysis with adjustment for location and clinicodemographic parameters, the associations of PROs with the enrollment setting (real-life Global Liver Registry vs. clinical trials) were no longer significant (all p > 0.10). The clinico-demographic portrait of CHB patients varies across regions of the world and enrollment settings. Advanced fibrosis and non-hepatic comorbidities are independently associated with PRO impairment in CHB patients.
Keywords
Emotional well-being, Fatigue, Fatty liver, Physical functioning, Viral hepatitis, Work productivity
Publication Title
Journal of Viral Hepatitis
Recommended Citation
Younossi, Zobair M.; Yu, Ming-Lung; Yilmaz, Yusuf; Alswat, Khalid Aida; Buti, Maria; Fernandez, Marlen Ivon Castellanos; Papatheodoridis, Georgios; Hamid, Saeed S.; El-Kassas, Mohamed; Chan, Wah Kheong; Duseja, Ajay K.; Gordon, Stuart C.; Eguchi, Yuichiro; Isakov, Vasily A.; Roberts, Stuart K.; Fan, Jian-Gao; Singal, Ashwani K.; Romero-Gomez, Manuel; Ahmed, Aijaz; Ong, Janus; Lam, Brian P.; Younossi, Issah; Nader, Fatema; Racila, Andrei; Stepanova, Maria; and Alqahtani, Saleh, "Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry (TM)" (2023). Research Publications (2021 to 2025). 2857.
https://knova.um.edu.my/research_publications_2021_2025/2857
Divisions
medicinedept
Funders
Center for Outcomes Research in Liver Diseases (COR-LD), Washington, DC, USA
Volume
30
Issue
4
Publisher
Wiley
Publisher Location
111 RIVER ST, HOBOKEN 07030-5774, NJ USA