Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment
Document Type
Article
Publication Date
4-1-2023
Abstract
Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/ 5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 +/- 3.46 nm and +23 +/- 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/ 5FU nanocomposites with an average diameter of 37.16 +/- 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity.
Keywords
Polysaccharides, Magnetic nanocomposites, Drug delivery systems, Cytotoxicity assay, Colorectal cancer
Divisions
InstituteofBiologicalSciences
Funders
Takasago Thermal Engineering Co. Ltd.,Sunway University Internal Grant Scheme 2022 (R.K.130000.7343.4B422),Sunway University Internal Grant Scheme 2022 (GRTIN-IGS-DMS (S)-04-2022)
Publication Title
International Journal of Biological Macromolecules
Volume
233
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS