Synthesis, characterization and in-vitro biocompatibility of electrophoretic deposited europium-doped calcium silicate on titanium substrate
Document Type
Article
Publication Date
3-1-2023
Abstract
Europium (Eu) has attracted attention to be incorporated as biologically active ions to achieve different biological and functional properties of biomaterials. In this study, calcium silicate (CS) coatings doped with different amount of Eu (up to 10 mol%) were successfully formed on titanium substrates via electrophoretic deposition. A low amount of Eu (2.5 mol%) gave a relatively denser coating and improved coating adhesion strength (similar to 3.3 N). All Eu-CS coatings provided good apatite forming ability, yet lower degradation rate, as compared to CS coating. Moreover, it was observed that the human fetal osteoblast (hFOB) cells could attach and proliferate on all Eu-CS coatings, suggesting their biocompatible nature. Eu2.5CS not only showed comparable cell proliferation with CS, but also enhanced the osteogenic activity of the CS coating. All results suggested that Eu2.5CS coatings are promising coating materials for biomedical implants, particularly bone tissue engineering applications.
Keywords
Calcium silicate, Europium, Coating, Electrophoretic deposition, Biocompatibility
Divisions
fac_eng,biomedengine,sch_che,mechanical
Funders
Ministry of Education, Malaysia,Fundamental Research Grant Scheme (FRGS) (FP048-2019A),Universiti Malaya of Malaysia through the Postgraduate Research Grant (PG114-2015A),MOHE via MyBrain15-MyPhD program
Publication Title
Journal of the European Ceramic Society
Volume
43
Issue
3
Publisher
Elsevier
Publisher Location
125 London Wall, London, ENGLAND