Preliminary study of longitudinal changes in the pituitary and brain of children on growth hormone therapy
Document Type
Article
Publication Date
3-1-2023
Abstract
Background: In subjects with isolated growth hormone deficiency (IGHD), recombinant human growth hor-mone (rhGH) is an approved method to achieve potential mid-parental height. However, data reporting rhGH treatment response in terms of brain structure volumes were scarce. We report the volumetric changes of the pituitary gland, basal ganglia, corpus callosum, thalamus, hippocampus and amygdala in these subjects post rhGH treatment. Materials and methods: This was a longitudinal study of eight IGHD subjects (2 males, 6 females) with a mean age of 11.1 +/- 0.8 years and age-matched control groups. The pituitary gland, basal ganglia and limbic struc-tures volumes were obtained using 3T MRI voxel-based morphology. The left-hand bone age was assessed using the Tanner-Whitehouse method. Follow-up imaging was performed after an average of 1.8 +/- 0.4 years on rhGH.Results: Subjects with IGHD had a smaller mean volume of the pituitary gland, right thalamus, hippocampus, and amygdala than the controls. After rhGH the
Keywords
Isolated growth hormonedeficiency, Recombinant human growth hormone, MRI, Volume, Pituitary
Divisions
fac_med,biomed,paediatrics
Publication Title
Journal of Neuroradiology
Volume
50
Issue
2
Publisher
Elsevier
Publisher Location
21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE