Chlamydia trachomatis plasmid-encoding Pgp3 protein induces secretion of distinct inflammatory signatures from HeLa cervical epithelial cells
Document Type
Article
Publication Date
3-1-2023
Abstract
BackgroundGenital Chlamydia trachomatis infection is the most common bacterial sexual transmitted disease that causes severe complications including pelvic inflammatory disease, ectopic pregnancy, and infertility in females. The Pgp3 protein encoded by C. trachomatis plasmid has been speculated to be an important player in chlamydial pathogenesis. However, the precise function of this protein is unknown and thus remains to be thoroughly investigated.MethodsIn this study, we synthesized Pgp3 protein for in vitro stimulation in the Hela cervical carcinoma cells.Results and conclusionWe showed that Pgp3 induced prominent expression of host inflammatory cytokine genes including interleukin-6 (IL-6), IL-8, tumor necrosis factor alpha-induced protein 3 (TNFAIP3), and chemokine C-X-C motif ligand 1 (CXCL1), implying a possible role of Pgp3 in modulating the inflammatory reaction in the host.
Keywords
Chlamydia trachomatis, Pgp3, Cytokine, Chemokine, IL-6, IL-8, TNFAIP, CXCL1
Divisions
fac_med
Publication Title
BMC Microbiology
Volume
23
Issue
1
Publisher
BMC
Publisher Location
CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND