Maitake medicinal mushroom, Grifola frondosa (Agaricomycetes), and its neurotrophic properties: A mini-review
Document Type
Article
Publication Date
1-1-2023
Abstract
Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon. Neurologic conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) are challenging to treat due to their irreversible manner as well as the lack of effective treatment. Grifola frondosa (Dicks.: Fr.) S.F. Gray, or maitake mushroom, is believed to be a potential choice as a therapeutic agent for neurodegenerative diseases. G. frondosa is known to be a functional food that has a wide variety of medicinal purposes. Thus, this review emphasizes the neuroprotective effects and the chemical composition of G. frondosa. Various studies have described that G. frondosa can protect and proliferate neuronal cells through neurogenesis, antioxidative, anti-inflammatory, and anti-beta-amyloid activities. The mechanism of action behind these therapeutic findings in various in vitro and in vivo models has also been intensively studied. In this mini review, we also summarized the chemical composition of G. frondosa to provide a better understanding of the presence of nutritional compounds in G. frondosa.
Keywords
Grifola frondosa, Neurodegeneration, Antioxidative, Anti-inflammatory, Anti-beta-amyloid, Tau protein, Medicinal mushrooms
Divisions
pharlife
Funders
Ministry of Higher Education, Malaysia,FP016-2019A, FRGS/1/2019/ SKK09/UM/02/2
Publication Title
International Journal of Medicinal Mushrooms
Volume
25
Issue
2
Publisher
Begell House Inc.
Publisher Location
50 NORTH ST, DANBURY, CT 06810 USA