Potential value of visfatin, omentin-1, nesfatin-1 and apelin in renal cell carcinoma (RCC): A systematic review and meta-analysis
Document Type
Article
Publication Date
12-1-2022
Abstract
Renal cell carcinoma (RCC) is the most lethal genitourinary malignancy. Obesity is a risk factor for RCC development. The role of adipokines in the relationship between obesity and RCC requires confirmatory evidence in the form of a systematic review and meta-analysis, specifically for visfatin, omentin-1, nesfatin-1 and apelin. A search of databases up to July 2022 (PubMed, Web of Science and Scopus) for studies reporting the association of these selected adipokines with RCC was conducted. A total of 13 studies fulfilled the selection criteria. Only visfatin (p < 0.05) and nesfatin-1 (p < 0.05) had a significant association with RCC. Meanwhile, apelin and omentin-1 showed no association with RCC. The meta-analysis results of nesfatin-1 showed no association with early-stage (OR = 0.09, 95% CI = -0.12-0.29, p = 0.41), late-stage (OR = 0.36, 95% CI = 0.07-1.89, p = 0.23) and low-grade (OR = 1.75, 95% CI = 0.37-8.27, p = 0.48) RCC. However, nesfatin-1 showed an association with a high grade of the disease (OR = 0.29, 95% CI = 0.13-0.61, p = 0.001) and poorer overall survival (OS) (HR = 3.86, 95% CI = 2.18-6.85; p < 0.01). Apelin showed no association with the risk of RCC development (mean difference = 21.15, 95% CI = -23.69-65.99, p = 0.36) and OS (HR = 1.04, 95% Cl = 0.45-2.41; p = 0.92). Although the number of studies evaluated was limited, analysis from this systematic review and meta-analysis indicate that visfatin and nesfatin-1 were elevated. In summary, these adipokines may play a role in the development and progression of RCC and hence may have potential diagnostic and prognostic capabilities for RCC.
Keywords
Adipokine, Kidney cancer, Marker, Prognosis, Obesity
Divisions
surgerydept
Funders
Ministry of Higher Education (MOHE), Malaysia, under the Fundamental Research Grant Scheme (FRGS) (Grant No: FP100-2020)
Publication Title
Diagnostics
Volume
12
Issue
12
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND