Anti-breast cancer activity of essential oil: A systematic review
Document Type
Article
Publication Date
12-1-2022
Abstract
Breast cancer is the second highest cancer-related death worldwide. The treatment for breast cancer is via chemotherapy; however, occurrences of multidrug resistance, unselective targets, and physicochemical problems suggest that chemotherapy treatment is ineffective. Therefore, there is a need to find better alternatives. Essential oil is a plant secondary metabolite having promising bioactivities and pharmacological effects, including anti-breast cancer capabilities. This review intends to discuss and summarize the effect of essential oils on anti-breast cancer from published journals using keywords in PubMed, Scopus, and Google Scholar databases. Our findings reveal that the compositions of essential oils, mainly terpenoids, have excellent anti-breast cancer pharmacological effects with an IC50 value of 0.195 mu g/mL. Hence, essential oils have potential as anti-breast cancer drugs candidates with the highest efficacy and the fewest side effects.
Keywords
Breast cancer, Essential oils, Terpenoids
Divisions
InstituteofBiologicalSciences
Funders
Rector Universitas Padjadjaran, Indonesia 2203/UN6.3.1/PT.00/2022
Publication Title
Applied Sciences-Basel
Volume
12
Issue
24
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND