Phase angle and diabetes in community-dwelling older adults: cross-sectional analysis from the Malaysian elders longitudinal research (MELoR) study
Document Type
Article
Publication Date
5-1-2022
Abstract
Objective To evaluate the role of PhA in diabetes in a large population of older adults with a high prevalence of diabetes in order to gain new insights on the potential diagnostic and prognostic role of PhA in individuals with diabetes. Design Cross-sectional study. Setting Teaching Hospital. Participants 1085 individuals aged 55 years or over. Measurements Phase Angle was obtained using bioimpedance analysis with the Bodystat QuadScan(R) 4000. Diabetes mellitus was considered present with fasting hyperglycaemia (serum fasting glucose >6.66 mmol/l), HbA1c > 42 mmol/mol (6.1%), or self-reported Diabetes or the consumption of glucose-lowering agents. Results The mean age of the (standard deviation) of the 1,085 participants was 68.11 (7.12) years and 60.7% were women. Among male participants, individuals with PhA within the lowest quartile (PhA <= 4.9) were significantly more likely to have diabetes mellitus odds Ratio (95% confidence interval, CI), 2.02 (1.17-3.47)] following adjustments for age, body mass index and other comorbidities. The above relationship was attenuated following further adjustment hypoglycaemic medications. Men on oral hypoglycaemic agents had significantly reduced PhA mean difference (95% CI), -0.44 (-0.67 to -0.22)]. No significant relationship between PhA and diabetes existed among women. Conclusion The association between lower PhA (<= 4.9) in men aged 55 and over and diabetes which is accounted for by oral hypoglycaemic agents. The mechanisms underlying this relationship remain unclear. This relationship should also be evaluated further to determine the potential of PhA as a prognostic tool for diabetes.
Keywords
Phase angle, diabetes, Malaysian elders longitudinal research (MELoR)
Divisions
fac_med
Funders
Ministry of Higher Education Malaysia Long Term Research Grant Scheme (Grant No. (LR005-2019) LRGS/1/2019/UM//1/1)
Publication Title
European Journal Of Clinical Nutrition
Volume
76
Issue
5
Publisher
Springernature
Publisher Location
CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND