Clostridia isolated from helminth-colonized humans promote the life cycle of Trichuris species
Document Type
Article
Publication Date
11-1-2022
Abstract
Soil-transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia, individual species have not been isolated and characterized. Here, we isolate and sequence the genome of 13 Clostridia from the Orang Asli, an indigenous population in Malaysia with a high prevalence of helminth infections. Metagenomic analysis of 650 fecal samples from urban and rural Malaysians confirm the prevalence of species corresponding to these isolates and reveal a specific association between Peptostrep-tococcaceae family members and helminth colonization. Remarkably, Peptostreptococcaceae isolated from the Orang Asli display superior capacity to promote the life cycle of whipworm species, including hatching of eggs from Trichuris muris and Trichuris trichiura. These findings support a model in which helminths select for gut colonization of microbes that support their life cycle.
Keywords
REGULATORY T-CELLS, GUT MICROBIOTA, CONSEQUENCES, INFLAMMATION, INFECTIONS, INDUCTION, INTESTINE, SEQUENCE, IMMUNITY, STRAINS
Divisions
biomedsc,Parasit
Funders
United States Department of Health & Human Services National Institutes of Health (NIH) - USA,Howard Hughes Medical Institute,Crohn's & Colitis Foundation of America,Kenneth Rainin Foundation,Judith & Stewart Colton Center of Autoimmunity,NYU Langone Health Antimicrobial-Resistant Pathogens Program,PacBio Local SMRT Grant,Intramural Research Program of NIAID
Publication Title
CELL REPORTS
Volume
41
Issue
9
Publisher
CELL PRESS
Publisher Location
50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA