Evolving perspectives on rosetting in malaria

Document Type

Article

Publication Date

10-1-2022

Abstract

The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically im-portant malaria parasites. Since the discovery of rosettes in the late 1980s, differ-ent formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent break-throughs, including new data from Plasmodium vivax, have highlighted the multi-faceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the for-mation and the role of rosetting in malaria rheopathobiology.

Keywords

Rosetting, Malaria, Red blood cells, Membrane protein

Publication Title

Trends In Parasitology

Divisions

Parasit

Funders

Open Fund -Young Individual Research grant by the National Medical Research Council (NMRC) , Singapore (OF-YIRG NMRC/OFYIRG/0070/2018),Long Term Research Grant Scheme (LRGS) of the Ministry of Higher Education, Malaysia (LRGS/1/2018/UM/01/1/1),Agency for Science Technology & Research (A*STAR) (JCO-DP BMSI/15-800006),HRC e -ASIA grant (17/678),University of Otago Deans Bequest Grant

Volume

38

Issue

10

Publisher

Elsevier Sci Ltd

Publisher Location

THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND

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