Evolving perspectives on rosetting in malaria
Document Type
Article
Publication Date
10-1-2022
Abstract
The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically im-portant malaria parasites. Since the discovery of rosettes in the late 1980s, differ-ent formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent break-throughs, including new data from Plasmodium vivax, have highlighted the multi-faceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the for-mation and the role of rosetting in malaria rheopathobiology.
Keywords
Rosetting, Malaria, Red blood cells, Membrane protein
Divisions
Parasit
Funders
Open Fund -Young Individual Research grant by the National Medical Research Council (NMRC) , Singapore (OF-YIRG NMRC/OFYIRG/0070/2018),Long Term Research Grant Scheme (LRGS) of the Ministry of Higher Education, Malaysia (LRGS/1/2018/UM/01/1/1),Agency for Science Technology & Research (A*STAR) (JCO-DP BMSI/15-800006),HRC e -ASIA grant (17/678),University of Otago Deans Bequest Grant
Publication Title
Trends In Parasitology
Volume
38
Issue
10
Publisher
Elsevier Sci Ltd
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND