Blood pressure variability and cognitive function: A scoping review
Document Type
Article
Publication Date
10-1-2022
Abstract
To conduct a scoping review of articles which have evaluated BPV and cognitive function. Articles with keywords, titles or abstracts containing the terms `cognitive' OR `cognition' OR `dementia' AND `blood pressure variability' were identified from CINAHL, Medline, PMC and Web of Science. Recent Findings Methods of acquisition and analysis of BPV and cognitive measurements and their relationship were extracted from selected articles. Of 656 studies identified, 53 articles were selected. Twenty-five evaluated long-term (LTBPV), nine mid-term (MTBPV), 12 short-term (STBPV) and nine very short-term BPV (VSTBPV) with conflicting findings on the relationship between BPV and cognition. Variations existed in devices, period and procedure for acquisition. The studies also utilized a wide range of methods of BPV calculation. Thirteen cognitive assessment tools were used to measure global cognition or domain functions which were influenced by the population of interest. The interpretation of available studies was hence limited by heterogeneity. There is an urgent need for standardization of BPV assessments to streamline research on BPV and cognition. Future studies should also establish whether BPV could be a potential modifiable risk factor for cognitive decline, as well as a marker for treatment response.
Keywords
Aged, Cognition, Dementia, Blood pressure, Blood pressure variability
Divisions
fac_med
Funders
Ministry of Higher Education Long Term Research Grant Scheme [LRGS/1/2019/UM/01/1]
Publication Title
Current Hypertension Reports
Volume
24
Issue
10
Publisher
Springer
Publisher Location
ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES