Tri-metallic Co-Ni-Cu based metal organic framework nanostructures for the detection of an anticancer drug nilutamide
Document Type
Article
Publication Date
7-1-2021
Abstract
This work reports a biosensor based on tri-metallic organic framework (MOF) for the determination of an anticancer therapeutic agent, nilutamide (NLM). The tri-metallic Co-Ni-Cu-MOF and the single metal MOFs Co-MOF, Ni-MOF and Cu-MOF were grown onto nickel foam (NF) substrate by a solvothermal method. The crystal, chemical structure, morphology and surface area of the MOFs were studied by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis. The electrochemical sensing of NLM by the Co-Ni-Cu-MOF/NF and the single metal MOFs grown onto NF were studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The CV of the Co-Ni-Cu-MOF/NF shows a redox couple between-0.4 V and 0.3 V in phosphate buffer solution at pH 7.0. The Co-Ni-Cu-MOF/NF sensor shows a strong electrocatalytic activity towards the redox reaction of NLM with a broad concentration range from 0.5-70 mu M and 70-900 mu M with high sensitivity of 10.712 mu A mu M-1 cm(-2) and a low limit of detection of 0.48 +/- 0.02 nM. These results confirm that the tri-metallic MOF possesses high selectivity and sensitivity for the determination of NLM from human serum specimen and pharmaceutical tablet dosage forms. (C) 2021 Elsevier B.V. All rights reserved.
Keywords
Tri-metallic Co-Ni-Cu-MOF/NF, Biosensor, Nilutamide, Differential pulse voltammetry, Cyclic voltammetry, Real samples
Divisions
Science
Funders
Universiti Malaya,University Malaysia Pahang[PG226-2015A],University Malaysia Pahang[PGRS170394],Ministry of Higher Education (MOHE) Malaysia[RU2020],Ministry of Higher Education (MOHE) Malaysia[RH 2017],Ministry of Higher Education (MOHE) Malaysia[RDU190142],STAR Project Ministry of Human Resource and Development, Govt. of India[STARS/APR2019/NS/428/FS]
Publication Title
Sensors and Actuators A-Physical
Volume
325
Publisher
Elsevier Science SA
Publisher Location
PO BOX 564, 1001 LAUSANNE, SWITZERLAND