Efficient synthesis of some V-shaped methylene-bridged compounds via regioselective condensation

Authors

• Afsaneh Zonouzi
• Fatemeh Hosseinzadeh
• Shahrzad Dehdari
• Alireza Abbasi
• Seik Weng Ng

Document Type

Article

Publication Date

7-1-2021

Abstract

A number of new stable methanobenzo7,8]1,3] dioxocino4,5-d]pyrimidine-1,3(2H)-dione derivatives (4a-l) were synthesized using a simple one-pot procedure with considerable efficiency. Reaction parameters were further optimized in order to achieve a single-product procedure. Plausible routes for reaction progress were investigated and it was proved that the reaction goes through regioselective condensation yielding an interesting V-shaped structure. Spectral data of all products under study were used to elucidate the chemical structure and X-ray structure analysis was performed to unambiguously prove the proposed structure for 4c.

Keywords

Barbituric acid, Chromene, Methylene bridged, regioselective condensation, V-shaped molecules

Publication Title

Journal of the Chinese Chemical Society

Recommended Citation

Zonouzi, Afsaneh; Hosseinzadeh, Fatemeh; Dehdari, Shahrzad; Abbasi, Alireza; and Ng, Seik Weng, "Efficient synthesis of some V-shaped methylene-bridged compounds via regioselective condensation" (2021). Research Publications (2021 to 2025). 12520.
https://knova.um.edu.my/research_publications_2021_2025/12520

Divisions

Science

Funders

Research Council of the University of Tehran

Volume

68

Issue

7

Publisher

Chinese Chemical Society Taiwan

Publisher Location

POSTFACH 101161, 69451 WEINHEIM, GERMANY