Efficient synthesis of some V-shaped methylene-bridged compounds via regioselective condensation
Document Type
Article
Publication Date
7-1-2021
Abstract
A number of new stable methanobenzo7,8]1,3] dioxocino4,5-d]pyrimidine-1,3(2H)-dione derivatives (4a-l) were synthesized using a simple one-pot procedure with considerable efficiency. Reaction parameters were further optimized in order to achieve a single-product procedure. Plausible routes for reaction progress were investigated and it was proved that the reaction goes through regioselective condensation yielding an interesting V-shaped structure. Spectral data of all products under study were used to elucidate the chemical structure and X-ray structure analysis was performed to unambiguously prove the proposed structure for 4c.
Keywords
Barbituric acid, Chromene, Methylene bridged, regioselective condensation, V-shaped molecules
Divisions
Science
Funders
Research Council of the University of Tehran
Publication Title
Journal of the Chinese Chemical Society
Volume
68
Issue
7
Publisher
Chinese Chemical Society Taiwan
Publisher Location
POSTFACH 101161, 69451 WEINHEIM, GERMANY