The intellicage system: A review of its utility as a novel behavioral platform for a rodent model of substance use disorder
Document Type
Article
Publication Date
6-4-2021
Abstract
The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
Keywords
IntelliCage system, substance use disorder (SUD), addiction, rodent model, behavior, home cage
Divisions
biomed
Funders
Universiti Sains Malaysia [304/PPSP/6315252] [1001/PPSP/8012300],Universiti Kebangsaan Malaysia (UKM) Dana Fundamental [FF-2019-098],National Science Centre, Poland [2019/35/B/NZ4/04077]
Publication Title
Frontiers In Behavioral Neuroscience
Volume
15
Publisher
Frontiers Media SA
Publisher Location
AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND