Does HIV infection affect the survival of dental implants? A systematic review and meta-analysis
Document Type
Article
Publication Date
6-1-2021
Abstract
Statement of problem. Immunosuppression and coinfections associated with human immunodeficiency virus (HIV) infection pose a relative contraindication for dental implant therapy. However, although implants have been placed in patients with HIV with reasonable success, how HIV infection affects their survival is unclear. Purpose. The purpose of this systematic review of the literature and meta-analysis was to analyze the data on the survival of dental implants in patients with HIV. Material and methods. A search for relevant articles published up to November 2019 was performed in PubMed/Medline and Cochrane databases, Clinicaltrials.gov, and Google Scholar. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted for the conduct of the systematic review. The most pertinent data were extracted and pooled for qualitative and quantitative analyses with 95% confidence intervals. Heterogeneity was analyzed by using I-squared statistics. Results. A total of 8 studies involving 411 individuals with HIV and 1109 implants were included in the meta-analysis. The mean follow-up period was 2.8 years. A pooled estimate of 95% of implant survival rate with 95% confidence interval(92% to 96%) was noted. Heterogeneity across the 8 studies was found to be 41% with moderate true variability. Conclusions. This systematic review demonstrated that HIV infection does not pose a serious threat to implant survival on short-term evaluation, but the evidence is of low quality. (J Prosthet Dent 2021;125:862-9)
Keywords
HIV infection, Dental implants
Divisions
Dentistry
Publication Title
The Journal of Prosthetic Dentistry
Volume
125
Issue
6
Publisher
Elsevier
Publisher Location
360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA