Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats

Document Type

Article

Publication Date

9-10-2022

Abstract

This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities.

Keywords

ANGIOGENESIS, EXTRACT, REPAIR

Publication Title

BioMed Research International

Divisions

InstituteofBiologicalSciences

Funders

Universiti Malaya [PG059-2013A]

Volume

2022

Publisher

Hindawi Publishing Corporation

Publisher Location

ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND

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