Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats
Document Type
Article
Publication Date
9-10-2022
Abstract
This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities.
Keywords
ANGIOGENESIS, EXTRACT, REPAIR
Divisions
InstituteofBiologicalSciences
Funders
Universiti Malaya [PG059-2013A]
Publication Title
BioMed Research International
Volume
2022
Publisher
Hindawi Publishing Corporation
Publisher Location
ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND