Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia
Document Type
Article
Publication Date
5-17-2021
Abstract
Background Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans. Methods A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia. Results Epidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time. Conclusions The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks.
Keywords
Enterovirus, Coxsackievirus, Acute respiratory tract infections, Outbreak
Divisions
medicinedept
Funders
Ministry of Education, Malaysia [UM.C/625/1/HIR/MOE/CHAN/02/02],Ministry of Higher Education, Malaysia [FRGS/1/2020/SKK0/UM/02/17],Ministry of Higher Education, Malaysia [GPF002C-2019]
Publication Title
BMC Infectious Diseases
Volume
21
Issue
1
Publisher
BMC
Publisher Location
CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND