Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches
Document Type
Article
Publication Date
4-1-2021
Abstract
Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction methods applied in several studies for skin regeneration, which are classified into the cell, growth factor, scaffold, and biological/chemical compound-based strategies. In addition, the advantages and disadvantages of these angiogenic strategies along with related research examples are discussed in order to demonstrate their potential in the treatment of wounds.
Keywords
Angiogenesis, Biomaterials, Chronic wound, Skin tissue engineering, Wound healing
Divisions
fac_med
Publication Title
Journal of Biomedical Materials Research Part A
Volume
109
Issue
4
Publisher
Wiley
Publisher Location
111 RIVER ST, HOBOKEN 07030-5774, NJ USA