Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
Document Type
Article
Publication Date
4-1-2021
Abstract
MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy.
Keywords
Clinical biomarker, Extracellular vesicles, High blood pressure, Microvesicles, Small noncoding RNA
Divisions
fac_med,pharmacy
Funders
Ministry of Education, Malaysia [Grant No: FRGS/1/2015/SKK08/UNIM/03/2 & FRGS/1/2019/SKK08/UNIM/02/2]
Publication Title
American Journal of Physiology-Heart and Circulatory Physiology
Volume
320
Issue
4
Publisher
Amer Physiological Soc
Publisher Location
9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA