“Mummy, my eyelids are heavy”: A case series of juvenile myasthenia gravis
Document Type
Article
Publication Date
3-1-2021
Abstract
Purpose: To report three cases of juvenile myasthenia gravis aged between 18 and 24 months with ocular symptoms as their first presentation. Method: A case series. Results: We present a case series of juvenile myasthenia gravis in a tertiary centre in Malaysia. Two of the three cases consist of a pair of twins who presented with ptosis of bilateral eyes; the first twin presented 4 months later than the second twin. These two cases were positive for anti-acetylcholine receptor antibodies and had generalized myasthenia gravis, whereas the other case was negative for receptor antibodies and was purely ocular myasthenia gravis. Conclusion: Juvenile myasthenia gravis is relatively rare in toddlers. Early diagnosis and commencement of treatment is important to slow the progression of the disease and avoiding life-threatening events. © The Author(s) 2019.
Keywords
Cholinergic receptor antibody, Immunoglobulin, Prednisolone, Pyridostigmine, Autoantibody, Cholinergic receptor, Cholinesterase inhibitor, Glucocorticoid, Prednisolone, Pyridostigmine, Antibody titer, Article, Case report, Child, Clinical article, Divergent strabismus, Eye movement, Eyelid, Female, Human, Juvenile myasthenia gravis, Multiple cycle treatment, Myasthenia gravis, Nuclear magnetic Resonance imaging, Plasmapheresis, Pneumonia, Preschool child, Ptosis (Eyelid), Visual acuity, Blood, Combination drug therapy, Genetics, Immunology, Infant, Monozygotic twins, Myasthenia gravis, Ptosis, Twins, Autoantibodies, Blepharoptosis, Child, Preschool, Cholinesterase inhibitors, Diseases In twins, Drug Therapy, Combination, Female, Glucocorticoids, Humans, Infant, Myasthenia Gravis, Prednisolone, Pyridostigmine bromide, Receptors, Cholinergic, Twins, Monozygotic
Divisions
ophthalmplogy
Funders
None
Publication Title
European Journal of Ophthalmology
Volume
31
Issue
2
Publisher
SAGE Publications