Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography

Authors

• Awais Khalid
• Pervaiz Ahmad
• Abdulrahman I. Alharthi
• Saleh Muhammad
• Mayeen Uddin Khandaker
• Mohammad Rashed Iqbal Faruque
• Israf Ud Din
• Mshari A. Alotaibi

Document Type

Article

Publication Date

2-1-2021

Abstract

Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 +/- 3 HU (without NPs) to 283.7 +/- 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.

Keywords

Nanoparticles, Titanium dioxide, Highly crystalline, Computed tomography

Publication Title

Crystals

Recommended Citation

Khalid, Awais; Ahmad, Pervaiz; Alharthi, Abdulrahman I.; Muhammad, Saleh; Khandaker, Mayeen Uddin; Iqbal Faruque, Mohammad Rashed; Din, Israf Ud; and Alotaibi, Mshari A., "Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography" (2021). Research Publications (2021 to 2025). 11393.
https://knova.um.edu.my/research_publications_2021_2025/11393

Funders

Research Universiti Grant, Universiti Kebangsaan Malaysia,Geran Universiti Penyelidikan (GUP)[2018-134]

Volume

11

Issue

2

Publisher

MDPI

Publisher Location

ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND