Unmodified titanium dioxide nanoparticles as a potential contrast agent in photon emission computed tomography
Document Type
Article
Publication Date
2-1-2021
Abstract
Highly crystalline titanium dioxide nanoparticles (TiO2-NPs) are synthesized via a simple hydrothermal technique. After structural and compositional analysis, the as-synthesized unmodified TiO2-NPs are tested for improvement in two modes of kilovoltage radiation therapy and single-photon emission computed tomography (SPECT)/computed tomography (CT). Our results show that the unmodified TiO2-NPs provide an observable enhancement in CT scan image contrast ranging from 0 +/- 3 HU (without NPs) to 283.7 +/- 3 HU (0.23 g/mL). TiO2-NPs has excellent biocompatibility, selective uptake at target sites, and reduced toxicity. The unmodified TiO2-NPs as a contrast agent can significantly improve the existing methods of diagnosing and treating cancer.
Keywords
Nanoparticles, Titanium dioxide, Highly crystalline, Computed tomography
Funders
Research Universiti Grant, Universiti Kebangsaan Malaysia,Geran Universiti Penyelidikan (GUP)[2018-134]
Publication Title
Crystals
Volume
11
Issue
2
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND