Docking evaluation of the interaction between green tea active ingredient, l-theanine and human serum albumin

Authors

• Amira Adlin Roslan
• Saharuddin B. MohamadFollow
• Saad Tayyab

Document Type

Article

Publication Date

2-1-2021

Abstract

Interaction of one of the green tea active ingredients, l-theanine with the major transport protein of human blood circulation, human serum albumin (HSA) was investigated using molecular docking analysis. Site-specific docking simulation suggested binding preference of l-theanine to Site 1 of HSA. The binding site is proposed to be a cleft surrounded by both polar and nonpolar residues. l-Theanine binds to the protein through hydrophobic interactions as well as hydrogen bonds formed between Lys residues (195 and 199) of HSA and l-theanine.

Keywords

l-Theanine, Human serum albumin, Molecular docking, Cluster analysis

Publication Title

National Academy Science Letters-India

Recommended Citation

Roslan, Amira Adlin; Mohamad, Saharuddin B.; and Tayyab, Saad, "Docking evaluation of the interaction between green tea active ingredient, l-theanine and human serum albumin" (2021). Research Publications (2021 to 2025). 11267.
https://knova.um.edu.my/research_publications_2021_2025/11267

Divisions

Science

Funders

Universiti Malaya [FG025-17AFR]

Volume

44

Issue

1

Publisher

Springer India

Publisher Location

7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001, INDIA