Movement disorders resulting from bilateral basal ganglia lesions in end-stage kidney disease: A systematic review
Document Type
Article
Publication Date
9-1-2022
Abstract
Objective The basal ganglia (BG) are susceptible to fluctuations in blood urea levels, sometimes resulting in movement disor-ders. We described patients with end-stage kidney disease (ESKD) presenting with movement disorders associated with bilateral BG lesions on imaging. Methods We report four patients and systematically reviewed all published cases of ESKD presenting with movement disor-ders and bilateral BG lesions (EBSCOhost and Ovid). Results Of the 72 patients identified, 55 (76.4%) were on regular dialysis. Parkinsonism was the most common movement disorder (n = 39; 54.2%), followed by chorea (n = 24; 33.3%). Diabetes mellitus (n = 51; 70.8%) and hypertension (n = 16; 22.2%) were the most common risk factors. Forty-three (59.7%) were of Asian ethnicity. Complete clinical resolution was reported in 17 (30.9%) patients, while 38 (69.1%) had incomplete clinical resolution with relapse. Complete radiological resolution occurred in 14 (34.1%) patients. Conclusion Movement disorders associated with BG lesions should be recognized as a rare and potentially reversible meta-bolic movement disorder in patients with ESKD
Keywords
Basal ganglia, Chorea, End-stage kidney disease, Magnetic resonance imaging, Parkinsonism
Divisions
medicinedept
Publication Title
Journal of Movement Disorders
Volume
15
Issue
3
Publisher
Korean Movement Disorders Soc
Publisher Location
2011 MAPO HANWHA OBELISK, 555, DOHWA-DONG, MAPO-GU, SEOUL, 04167, SOUTH KOREA