Gut-skin axis: Unravelling the connection between the gut microbiome and psoriasis
Document Type
Article
Publication Date
5-1-2022
Abstract
Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Dysregulation of microbiota has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis. Understanding how gut microbiome are involved in regulating skin health may lead to development of novel therapies for these skin disorders through microbiome modulation, in particularly psoriasis. In this review, we will compare the microbiota between psoriasis patients and healthy control, explain the concept of gut-skin axis and the effects of gut dysbiosis on skin physiology. We will also review the current evidence on modulating gut microbiome using probiotics in psoriasis.
Keywords
Microbiota, Skin Disease, Autoimmune Disease, Probiotic, Gut Dysbiosis
Divisions
InstituteofBiologicalSciences
Funders
Jeffrey Cheah School of Medicine and Health Sciences Strategic Grant 2021 [Grant No:STG-000051],External Industry Grant from Biomerge Sdn Bhd [Grant No:BMRG2018-01],University of Malaya Research Grant (FRGS) Grant No:FP022-2018A
Publication Title
Biomedicines
Volume
10
Issue
5
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND