Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies
Document Type
Article
Publication Date
1-15-2021
Abstract
In this study, zinc oxide-quercetin (ZnO-quercetin) nanocomposite was constructed as smart nano-drug delivery system. The amount of quercetin loaded onto the ZnO nanoparticle was found to be 210 mu g mg(-1). The quercetin release kinetics data indicates that the rate of quercetin release was faster in acidic condition (pH of typical cancer) compared to physiological condition. The molecular-level interaction of ZnO-quercetin nanocomposite formation was investigated by a combined experimental and theoretical investigation. The interaction studies have corroborated that 5-OH in the A-ring and 3-OH in the C-ring of quercetin were the most suitable positions for the ZnO interaction. The constructed ZnO-quercetin nanocomposite demonstrates an effective inhibition of the growth of breast cancer cells (MCF-7) with high biocompatibility (3T3-L1 cells). This study may provide a model path for the further development of smart nano-drug delivery system of metal oxides with hydrophobic natural drugs to treat cancer cells.
Keywords
Density functional theory, Flavonoids, Molecular interaction, Drug delivery system, Quercetin, Zinc oxide nanoparticles
Divisions
molecular
Funders
National Natural Science Foundation of China (NSFC) [21673085],Science and Technology Planning Project of Guangdong Province [2013B051000074 ],Guangdong-Hong Kong Technology Cooperation Funding Scheme [2017A050506048],Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
Publication Title
Applied Surface Science
Volume
536
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS