Three-year follow-up of 2-dose versus 3-dose HPV vaccine
Document Type
Article
Publication Date
1-1-2021
Abstract
Human papillomavirus (HPV) antibody responses to the 9-valent human papillomavirus (9vHPV) vaccine among girls and boys (aged 9-14 years) receiving 2-dose regimens (months 0, 6 or 0, 12) were noninferior to a 3-dose regimen (months 0, 2, 6) in young women (aged 16-26 years) 4 weeks after last vaccination in an international, randomized, open-label trial (NCT01984697). We assessed response durability through month 36. METHODS: Girls received 2 (months 0 and 6 0, 6]: n = 301; months 0 and 12 0, 12]: n = 151) or 3 doses (months 0,2, and 6 0, 2, 6]: n = 301); boys received 2 doses (0, 6]: n = 301; 0, 12]: n = 150); and young women received 3 doses (0, 2, 6]: n = 314) of 9vHPV vaccine. Anti-HPV geometric mean titers (GMTs) were assessed by competitive Luminex immunoassay (cLIA) and immunoglobulin G-Luminex immunoassay (IgG-LIA) through month 36. RESULTS: Anti-HPV GMTs were highest 1 month after the last 9vHPV vaccine regimen dose, decreased sharply during the subsequent 12 months, and then decreased more slowly. GMTs 2 to 2.5 years after the last regimen dose in girls and boys given 2 doses were generally similar to or greater than GMTs in young women given 3 doses. Across HPV types, most boys and girls who received 2 doses (cLIA: 81%-100%; IgG-LIA: 91%-100%) and young women who received 3 doses (cLIA: 78%-98%; IgG-LIA: 91%-100%) remained seropositive 2 to 2.5 years after the last regimen dose. CONCLUSIONS: Antibody responses persisted through 2 to 2.5 years after the last dose of a 2-dose 9vHPV vaccine regimen in girls and boys. In girls and boys, antibody responses generated by 2 doses administered 6 to 12 months apart may be sufficient to induce high-level protective efficacy through at least 2 years after the second dose.
Keywords
Human-Papillomavirus, Vaccine16/18, Age 9-14 years, Genotype
Publication Title
Pediatrics
Recommended Citation
Bornstein, Jacob; Roux, Surita; Petersen, Lone Kjeld; Huang, Li-Min; Dobson, Simon R.; Pitisuttithum, Punnee; Diez-Domingo, Javier; Schilling, Andrea; Ariffin, Hany Mohd; Tytus, Richard; Rupp, Richard; Senders, Shelly; Engel, Eli; Ferris, Daron; Kim, Yae-Jean; Kim, Young Tae; Kurugol, Zafer; Bautista, Oliver; Nolan, Katrina M.; Sankaranarayanan, Sandhya; Saah, Alfred; and Luxembourg, Alain, "Three-year follow-up of 2-dose versus 3-dose HPV vaccine" (2021). Research Publications (2021 to 2025). 11111.
https://knova.um.edu.my/research_publications_2021_2025/11111
Divisions
fac_med
Funders
Merck & Company
Volume
147
Issue
1
Publisher
Amer Acad Pediatrics
Publisher Location
141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA