Multimodality imaging features of breast carcinoma in women with Neurofibromatosis Type 1 (NF 1) - A report of two cases
Document Type
Article
Publication Date
1-1-2021
Abstract
With a prevalence of approximately 1 out of 2,500 to 4,000 births, neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease, is one of the most prevalent autosomal dominant diseases in humans. There is four to five-fold increased risk of malignancy in these patients due to the presence of NF1 gene mutation, which is a tumour suppressor inhibiting RAS activation. NF1 is known to be closely associated with central nervous system (CNS) tumours; however, its association with other non-CNS malignancies is not uncommon. Mutation of BRCA1 (breast cancer 1, early onset) and BRCA2 (breast cancer 2, susceptibility protein) genes has long been recognized as an important risk factor for the develpoment of breast cancer. Incidentally, BRCA1 and NF1 genes are both located in the long arm of chromosome 17. The association between NF1 and breast cancer has long been debated; recent studies, on the other hand, have established this association, with NF1 unequivocally identified as breast cancer susceptibility gene conferring a moderate risk of breast cancer development. In this report, we described multimodality imaging features of breast cancer in two women with NF1; we further reviewed the literatures on the association between NF1 and breast cancer and its diagnostic challenge.
Keywords
Neurofibromatosis type 1, Breast cancer, Risk factor, MRI
Divisions
biomed
Funders
Institutional grant [BK006-2018]
Publication Title
Middle East Journal of Cancer
Volume
12
Issue
1
Publisher
Shiraz Universityt Medical Sciences