Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
Document Type
Article
Publication Date
1-1-2021
Abstract
Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique ``clade-defining'' substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5MODIFIER LETTER PRIME-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
Keywords
Genome sequences, Potential fourth rhinovirus species, Rhinovirus A, Phylogenetic reconstruction
Divisions
medbio,medicinedept
Publication Title
Archives of Virology
Volume
166
Issue
1
Publisher
Springer Verlag (Germany)
Publisher Location
SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA