Facile in-situ fabrication of a ternary ZnO/TiO2/Ag nanocomposite for enhanced bactericidal and biocompatibility properties
Document Type
Article
Publication Date
1-1-2021
Abstract
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells.
Keywords
Antibacterial, Semiconductor materials, Nanocomposites, Precipitation, Cytotoxicity
Divisions
chemistry,fac_med,CHEMISTRY
Funders
University of Malaya-Ministry of Education, Malaysia [IIRG019B-2019],King Saud University [RSP-2020/185]
Publication Title
Antibiotics-Basel
Volume
10
Issue
1
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND