An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
Document Type
Article
Publication Date
1-1-2021
Abstract
The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (p < 0.001), with YSZ exhibiting the lowest permeability among all materials. Photofunctionalization of implant abutment materials improved the biological seal of the surrounding soft tissue peri-implant interface.
Keywords
Biological seal, Ultraviolet, Zirconia abutments, Photofunctionalization, Implant-soft tissue interface, organotypic model, three-dimensional peri-implant mucosal model
Divisions
OralMaxillofacialSurgery
Funders
Ministry of Higher Education High Impact Research Grant of Malaysia [UM.C/625/HIR/MOHE/DENT/05],Postgraduate Research Fund [PG355-2016A]
Publication Title
Biomedicines
Volume
9
Issue
1
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND