Pairwise correlation of genes involved in glucose metabolism: A potential diagnostic marker of cancer?
Document Type
Article
Publication Date
1-1-2021
Abstract
Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes ADH1B and PDHA2 were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer. Thus, the two differentially expressed genes and five gene pairs could be potential diagnostic markers for cancer. Further preclinical and clinical studies are warranted to prove whether these genes and/or gene pairs would indeed aid in early diagnosis of cancer. © 2021 Sakharkar et al.
Keywords
Diagnostic marker, Gene expression, Gene pair correlation, Pan-cancer analysis, Protein-protein interaction network
Divisions
InstituteofBiologicalSciences
Funders
University of Saskatchewan,Natural Sciences and Engineering Research Council of Canada (Grant No. 419247)
Publication Title
Genes and Cancer
Volume
12
Publisher
Impact Journals LLC