Derivation of an anti-cancer drug nanocarrier using a malonic acid-based deep eutectic solvent as a functionalization agent
Document Type
Article
Publication Date
9-1-2022
Abstract
Deep eutectic solvents (DESs) are novel `green' solvents that have recently gained considerable interest from diverse sectors of the scientific community. They are considered biocompatible, chemically stable, biodegradable, low-volatility, and non-flammable. In addition, the physicochemical properties of DESs are highly tunable and can be customized to meet the needs of a particular mission, including for its novel application in drug delivery systems. Here, graphene functionalized with the DES choline chloride:malonic acid was investigated for anti-cancer activity after loading with the drug doxorubicin. The DES-functionalized graphene demonstrated high drug loading efficiency and exhibited destructive effects against cancerous cells. Real-time cell growth analysis confirmed its cytotoxicity against cancerous cells over time. All told, the combination of choline chloride and malonic acid shows great promise as a green functionalizing agent for a nano-drug carrier, owing to its lower cytotoxicity, higher doxorubicin loading capacity, and inhibition of cancer cell growth profile.
Keywords
Ionic liquid, Drug delivery, Doxorubicin, Computational simulation, Graphene, Chemotherapy
Divisions
fac_med
Publication Title
Journal of Drug Delivery Science and Technology
Volume
75
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS