Epithelial dysplasia at excision margins of oral squamous cell carcinoma: A review on relationship to clinicopathological parameters and prognosis
Document Type
Article
Publication Date
1-1-2021
Abstract
Background: Epithelial dysplasia (ED) at oral cancer excision margins is a frequent finding. Dysplastic epithelium at excision margins may not be similar to dysplasia in Oral potentially malignant disorders (OPMD) as malignant transformation has already taken place. Therefore, management of ED at excision margins should be different to that of OPMD. ED creates a dilemma in relation to further management of cancer patients, since there are no accepted guidelines. Therefore, the objective of this review is to analyze existing literature and to arrive at evidence based recommendations for the management of ED at excision margins. Methods: A comprehensive string was run on PubMed, Medscape and Medline. The final outcome included 113 studies. Finally, the most relevant 10 articles were critically assessed for inclusion and exclusion criteria against various parameters. Results and Conclusions: Severe and Moderate ED need re-excision in order to improve prognosis. There is not enough sound evidence for the management of Mild ED at excision margins of oral squamous cell carcinoma. Guidelines for the management of ED at excision margins should be formulated after comprehensive multi center studies using lager cohorts of patients © 2021,Asian Pacific Journal of Cancer Prevention. All rights reserved
Keywords
Epithelial dysplasia, Excision margin, Oral squamous cell carcinoma, Prognosis
Divisions
Dentistry
Funders
None
Publication Title
Asian Pacific Journal of Cancer Prevention
Volume
22
Issue
8
Publisher
Asian Pacific Organization for Cancer Prevention