Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia
Document Type
Article
Publication Date
1-1-2021
Abstract
A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3 beta,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark ofAglaia angustifoliaMiq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1)showed strongest cytotoxic activity with an IC(50)value of 50.5 mu g/ml.
Keywords
Aglaia angustifolia, Angustifolianin, MCF-7, Meliaceae, Seco-apotirucallane
Divisions
CHEMISTRY
Publication Title
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume
23
Issue
8
Publisher
TAYLOR & FRANCIS LTD
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND