Document Type
Article
Publication Date
1-1-2016
Abstract
Genome-wide association studies (GWAS) have been successfully used to call for variants associated with diseases including type 2 diabetes mellitus (T2DM). However, some variants are not included in the GWAS to avoid penalty in multiple hypothetic testing. Thus, candidate gene approach is still useful even at GWAS era. This study attempted to assess whether genetic variations in the renin-angiotensin system (RAS) and their gene interactions are associated with T2DM risk. We genotyped 290 T2DM patients and 267 controls using three genes of the RAS, namely, angiotensin converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AGTR1). There were significant differences in allele frequencies between cases and controls for AGT variants () but not for ACE and AGTR1. Haplotype TCG of the AGT was associated with increased risk of T2DM (OR 1.92, 95% CI 1.15–3.20, permuted ); however, no evidence of significant gene-gene interactions was seen. Nonetheless, our analysis revealed that the associations of the AGT variants with T2DM were independently associated. Thus, this study suggests that genetic variants of the RAS can modestly influence the T2DM risk.
Keywords
Renin-Angiotensin System, Gene Variants, Type 2 Diabetes Mellitus, Influence, Angiotensinogen
Divisions
fac_med
Funders
University Malaya Research Grant RG056/09HTM,Postgraduate Research Fund PV057/2012A,University Malaya High Impact Research Grant UM.C/625/1/HIR/MOHE/MED/05
Publication Title
Journal of Diabetes Research
Volume
2016
Publisher
Hindawi Publishing Corporation