Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds
Document Type
Article
Publication Date
1-1-2016
Abstract
Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.
Keywords
Antibacterial Activity, Simulated Body Fluid, Bioactive Glass, Ga2O3, Composite Scaffold
Divisions
fac_eng
Funders
Ministry of Higher Education Malaysia: High Impact Research Grant (UM.C/625/1/HIR/MOHE/ENG/58),University of Malaya Research Grant (UMRG, RG156-12AET)
Publication Title
Journal of Materials Science: Materials in Medicine
Volume
27
Issue
1
Publisher
Kluwer (now part of Springer)