Bioresorbable and degradable behaviors of PGA: Current state and future prospects
Document Type
Article
Publication Date
11-1-2020
Abstract
Polyglycolic acid (PGA) is a class of semicrystalline, bioresorbable polymers that have been widely used in a number of applications. No other bioresorbable materials can fully replace PGA in tissue engineering. Understanding degradation mechanisms in PGA is important for improving the efficiency and effectiveness in various fields including implantation. This review begins with a discussion on terminology of polymer degradation and hydrolytic degradation mechanism with a delineative model. This review also focus on previous degradation studies taking advantage of its fast-degrading behavior and the mechanism behind hexafluoroisopropanol (HFIP) being the sole solvent for PGA. Finally, the merits of PGA are discussed with many potential future applications along with their associated challenges.
Keywords
bioresorbable polymer, degradation mechanism, hydrolytic degradation, polyglycolic acid, solubility in HFIP, tissue engineering
Divisions
sch_che
Funders
Ministry of Higher Education, Malaysia (Grant No. FP047‐2019A),Universiti Malaya (Grant No. FG010-17AFR, RP041A-17AET, RP041C-17AET)
Publication Title
POLYMER ENGINEERING AND SCIENCE
Volume
60
Issue
11
Publisher
WILEY
Publisher Location
111 RIVER ST, HOBOKEN 07030-5774, NJ USA