4,4 `-Trimethylenedipiperidine (TMDP): An efficient organocatalyst for the mechanosynthesis of pyrano4,3-b]pyrans under solid-state conditions
Document Type
Article
Publication Date
10-19-2020
Abstract
This paper presents a green protocol for the synthesis of pyrano4,3-b]pyrans using a catalytic amount of 4,4 `-trimethylenedipiperidine (TMDP) as a novel, efficient and recyclable organocatalyst through ball milling process at room temperature. The essential part of this protocol is a Knoevenagel condensation and to the best of our knowledge, this is the first report that exhibits the catalytic efficiency 4,4 `-TMDP for the one-pot multicomponent reaction under melt-state conditions. The scope of the present protocol was explored and demonstrated for the synthesis of pyrano4,3-b]pyrans in an environment-friendly protocol. The several interesting features of the present methodology are including a cost-effectiveness procedure, good to excellent yield of the desired products, high reaction rate, a broad substrate-scope, and recyclability of organocatalyst; as well as the 4,4 `-TMDP is a nontoxic, inexpensive, and commercially available catalyst. Furthermore, this efficient methodology displays a combination of the synthetic virtues of conventional multicomponent reaction with ecological benefits and convenience of a facile mechanochemical process.
Keywords
Ball mill process, Environmental benign conditions, Melt-state synthesis, One-pot multicomponent reaction, 4, 4′, -trimethylenedipiperidine
Divisions
nanotechnology
Publication Title
Polycyclic Aromatic Compounds
Volume
40
Issue
5
Publisher
Taylor & Francis
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND