Fatty acid based polyamide for application in drug delivery system: Synthesis, characterization, drug loading and in vitro drug release study
Document Type
Article
Publication Date
7-1-2020
Abstract
Application of degradable polymers for pharmaceutical formulations is an appropriate strategy to increase the efficacy and reduce the side effects of drugs. Methylprednisolone is a glucocorticoid used in the treatment of a wide range of inflammatory and immune disorders. Due to high rate of clearance of methylprednisolone from body, frequent administration is required which can increase its undesired effects. Therefore, the aim of this study was to prepare methylprednisolone loaded polymeric nanoparticles incorporating fatty acid based polyamide, to improve its efficacy and reduce the side effects. In this study, a new fatty acid based polyamide with ideal characteristics for application in pharmaceutical dosage forms was synthesized. Palmitic acid, a saturated fatty acid, a derivative of palm oil, was the main constituent of the polymer, which improved its degradability, flexibility, and hydrophobicity. Palmitic acid was functionalized by tris(2-aminoethyl)amine, and then polymerized by application of sebacoyl chloride as a cross linker. The structure of the polymer was confirmed by FTIR and (HNMR)-H-1 spectroscopy. Cytotoxicity of the polymer was tested on WRL68cell line using cell proliferation (MTT) assay, which showed low toxicity profile of the polymer. To study the type of erosion, polymeric devices were prepared by melt casting method by using aluminium mold. The polymer had about 55% and 40% wet and dry weight loss respectively within 7 days. The scanning electron micrographs showed surface erosion of the polymer. Drug loaded polymeric nanoparticles (PNP) were prepared by using thin film hydration method. Drug loaded PNPs with a particles size of 60-300 nm and entrapment efficiency of 76% were achieved.
Keywords
Fatty acid, Polyamide, Drug delivery systems, Polymeric nanoparticles, Methylprednisolone
Publication Title
Journal of Inorganic and Organometallic Polymers and Materials
Volume
30
Issue
7
Publisher
Springer
Publisher Location
VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS