European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Document Type
Article
Publication Date
7-1-2020
Abstract
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a similar to 2.7-fold risk and women in the lowest 1% of PRS distribution has similar to 0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.
Keywords
Adult, Aged, Asia, Breast Neoplasms, Case-Control Studies, Europe, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Multifactorial Inheritance, Odds Ratio, Polymorphism, Single Nucleotide, Prognosis, Risk
Divisions
biomed
Funders
Fondation CHU de Québec,Government of Canada,National University of Singapore,National Medical Research Council,Malaysian Ministry of Science,National Research Foundation of Korea [Grant No: C12292/ A20861, NRF-NRFF2017-02],Malaysian Ministry of Higher Education High Impact Research [Grant No: UM.C/HIR/MOHE/06]
Publication Title
Nature Communications
Volume
11
Issue
1
Publisher
Nature Research
Publisher Location
MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND